Virginia Commonwealth University

Make it real.

Featured Researcher

Research Expertise and Focus

  • Identifying and targeting small phospholipid molecules that regulate the development and progression of human ovarian, breast and prostate cancers
  • Regulation of lipogenesis by lysophophatidic acid in ovarian cancer. Funded 2011-2013 at $357,679 so far, by the National Center Institute, 5R21CA161478-02. Principal investigator

Professional Highlights

Membership and Leadership

  • Organizer/chair for the 44th SERLC (Southeastern Regional Lipid Conference), 2009

Editorial

  • Editorial board, World Journal of Clinical Oncology, 2010-2014

Education and Training

  • Ph.D., University of Toronto, Canada
  • M.S., Shanghai Medical University, China
  • B.S. Anhui Normal University, China
  • Post-doctoral work, University of Texas M.D. Anderson Cancer Center, Houston

Selected Publications

Zhang Y, Arnatt CK, Zhang F, Wang J, Haney KM, Fang X. The potential role of anibamine, a natural product CCR5 antagonist, and its analogues as leads toward development of anti-ovarian cancer agents. Bioorg Med Chem Lett. 2012 Aug1;22(15):5093-7. Epub 2012 Jun 16. PubMed PMID: 22770928.

Mukherjee A, Wu J, Barbour S, Fang X. Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells. J Biol Chem. 2012 Jul 20;287(30):24990-5000. doi: 10.1074/jbc.M112.340083. Epub 2012 Jun 3. PubMed PMID: 22665482; PubMed Central PMCID: PMC3408203. ·         Van DN, Roberts CF, Marion JD, Lépine S, Harikumar KB, Schreiter J, Dumur CI, Fang X, Spiegel S, Bell JK. Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics. FASEB J. 2012 Aug;26(8):3188-98. doi: 10.1096/fj.11-202333. Epub 2012 Apr 24.PubMed PMID: 22532440; PubMed Central PMCID: PMC3405273.

Wu J, Mukherjee A, Lebman DA, Fang X. Lysophosphatidic Acid-Induced p21Waf1 Expression Mediates the Cytostatic Response of Breast and Ovarian Cancer Cells to TGFβ. Mol Cancer Res. 2011 Nov 2. [Epub ahead of print] PubMed PMID: 21890597.

Li W, Mukherjee A, Wu J, Zhang L, Teves ME, Li H, Nambiar S, Henderson SC, Horwitz AR, Strauss Iii JF, Fang X, Zhang Z. Sperm Associated Antigen 6 (SPAG6) Regulates Fibroblast Cell Growth, Morphology, Migration and Ciliogenesis. Sci Rep. 2015 Nov 20;5:16506. doi: 10.1038/srep16506. PubMed PMID: 26585507; PubMed Central PMCID: PMC4653743.

Mukherjee A, Ma Y, Yuan F, Gong Y, Fang Z, Mohamed EM, Berrios E, Shao H, Fang X. Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells. Neoplasia. 2015 Sep;17(9):723-34. doi: 10.1016/j.neo.2015.09.003. PubMed PMID: 26476080; PubMed Central PMCID: PMC4611075.

Gu J, Hao J, Fang X, Sha X. Colloids Surf B Biointerfaces.  Factors influencing the transfection efficiency and cellular uptake mechanisms of Pluronic P123-modified polypropyleneimine/pDNA polyplexes in multidrug resistant breast cancer cells.  2016 Apr 1;140:83-93. doi: 10.1016/j.colsurfb.2015.12.023. Epub 2015 Dec 17.

Fang X, Xu Y, Wang S, Wan J, He C, Chen M. Pluronic F68-Linoleic Acid Nano-spheres Mediated Delivery of Gambogic Acid for Cancer Therapy. AAPS PharmSciTech. 2016 Feb 24. [Epub ahead of print] PMID:26912357

Gao S, Chen X, Jin H, Ren S, Liu Z, Fang X, Zhang G. Overexpression of ErbB2 renders breast cancer cells susceptible to 3-BrPA through the increased dissociation of hexokinase II from mitochondrial outer membrane. Oncol Lett. 2016 Feb;11(2):1567-1573. Epub 2015 Dec 21.

Wu J, Mukherjee A, Lebman DA, Fang X. Gene Expression of the Lysophosphatidic Acid Receptor 1 Is a Target of Transforming Growth Factor Beta. Oncogene. 2013 Jun 27;32(26):3198-206. PMCID: PMC3480976

Van DN, Roberts CF, Marion JD, Lépine S, Harikumar KB, Schreiter J, Dumur CI, Fang X, Spiegel S, Bell JK. Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics. FASEB J. 2012 Aug;26(8):3188-98. PMCID: PMC3405273

Mukherjee A, Wu J, Barbour S, Fang X. Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells. J Biol Chem. 2012 Jul 20;287(30):24990-5000. PMCID: PMC3408203

Wu J, Mukherjee A, Lebman DA, Fang X. Lysophosphatidic acid-induced p21Waf1 expression mediates the cytostatic response of breast and ovarian cancer cells to TGFβ. Mol Cancer Res. 2011 Nov;9(11):1562-70. PMCID: PMC3388908

Wijesinghe DS, Mayton EK, Mietla JA, Mukherjee A, Wu J, Fang X, Chalfant CE. Characterization of lysophosphatidic acid subspecies produced by autotaxin using a modified HPLC ESI-MS/MS method. Anal Methods. 2011 Nov 1;3(12):2822-2828. PMCID: PMC3956132

Ramachandran S, Shida D, Nagahashi M, Fang X, Milstien S, Takabe K, Spiegel S. Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription. FEBS Lett. 2010 Sep 24;584(18):4077-82. PMCID: PMC2947956

Oyesanya RA, Greenbaum S, Dang D, Lee Z, Mukherjee A, Wu J, Dent P, Fang X. Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid. Mol Cancer. 2010 Jan 14;9:8. PMCID: PMC2817642

Pamuklar Z, Federico L, Liu S, Umezu-Goto M, Dong A, Panchatcharam M, Fulkerson Z, Berdyshev E, Natarajan V, Fang X, van Meeteren LA, Moolenaar WH, Mills GB, Morris AJ, Smyth SS. Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem. 2009 Mar 13;284(11):7385-94. doi: 10.1074/jbc.M807820200. Epub 2009 Jan 12. PMCID: PMC2652269

Lee Z, Cheng CT, Zhang H, Subler MA, Wu J, Mukherjee A, Windle JJ, Chen CK, Fang X. Role of LPA4/p2y9/GPR23 in negative regulation of cell motility. Mol Biol Cell. 2008 Dec;19(12):5435-45. PMCID: PMC2592656

Yu S, Murph MM, Lu Y, Liu S, Hall HS, Liu J, Stephens C, Fang X, Mills GB. Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. J Natl Cancer Inst. 2008 Nov 19;100(22):1630-42. PMCID: PMC2720766

Shida D, Fang X, Kordula T, Takabe K, Lepine S, Alvarez SE, Milstien S, Spiegel S. Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Res. 2008 Aug 15;68(16):6569-77. PMCID: PMC2763580