Virginia Commonwealth University

Make it real.

Featured Researcher

Research Expertise and Focus

Reproductive biology research including the role of neutrophils in inflammation and epigenetic mechanisms relating to preclampsia andpreterm birth

Professional Highlights

Memberships and Leadership

  • Society for Gynecologic Investigation
  • The Endocrine Society
  • The American Physiological Society
  • Federation of American Societies for Experimental Biology
  • American Association for the Advancement of Science
  • Society for the Study of Reproduction
  • International Society for the Study of Hypertension in Pregnancy

Awards

  • Dean’s Teaching Excellence List
  • Phi Kappa Phi Honor Society
  • Won several SGI President’s Presenter Awards for presentations at the society

Notable

  • Paper published by Dr. Walsh in the American Journal of Obstetrics and Gynecology in 1985 concerning the imbalance in placental prostacyclin and thromboxane production in preeclampsial reached the status of “Citation Classic” as one of the most cited papers in Obstetrics and Gynecology during the past 50 years.

Education and Training

  • Ph.D., University Of Wisconsin-Madison
  • M.S., University Of Wisconsin-Madison
  • B.S., University Of Wisconsin-Milwaukee

Selected Publications

Nugent WH, Mishra N, Strauss JF 3rd, Walsh SW. Matrix Metalloproteinase 1 Causes Vasoconstriction and Enhances Vessel Reactivity to Angiotensin II via Protease-Activated Receptor 1. Reprod Sci. 2015 Oct 4. pii: 1933719115607998. [Epub ahead of print] PubMed PMID: 26438597.

Shukla J, Walsh SW. Neutrophil release of myeloperoxidase in systemic vasculature of obese women may put them at risk for preeclampsia. Reprod Sci. 2015 Mar;22(3):300-7. doi: 10.1177/193371911 4557899. Epub 2014 Nov 12. PubMed PMID: 25394640; PubMed Central PMCID: PMC4352145.

Castro-Leyva V, Espejel-Nuñez, Barroso G, Zaga-Clavellina V, Flores-Pliego A, Morales-Mendez I, Giono-Cerezo S,  Walsh SW, Estrada-Gutierrez G. Preserved ex vivo inflammatory status in decidual cells from women with preterm labor and subclinical intrauterine infection. PLoS One. 2012; 7(8): e43605. PMCID: PMC3425489

Mishra N, Nugent WH, Mahavadi S, Walsh SW. Mechanisms of enhanced vascular reactivity in preeclampsia. Hypertension. 2011 Nov; 58(5): 867–73. PMCID: PMC3212870

Vaidya SS, Walsh SW, Gerk PM. Application of human placental villous tissue explants to study ABC transporter mediated efflux of 2,4-dinitrophenyl-S-glutathione. Curr Pharm Biotechnol. 2011 May 1; 12(5): 814–23.  PMCID: PMC3086789

Estrada-Gutierrez G, Cappello RE, Mishra N, Romero R, Strauss JF 3RD, Walsh SW. Increased expression of matrix metalloproteinase-1 in systemic vessels of preeclamptic women: a critical mediator of vascular dysfunction. Am J Pathol. 2011 Jan; 178(1): 451–60.  PMCID: PMC3070570

Bachawaty T, Washington SL, Walsh SW. Neutrophil expression of cyclooxygenase 2 in preeclampsia. Reprod Sci. 2010 May; 17(5): 465–70. PMCID: PMC2850955

Shah TJ,  Leik CE, Walsh SW. Neutrophil infiltration and systemic vascular inflammation in obese women. Reprod Sci. 2010 Feb; 17(2): 116–24. PMCID: PMC2832323

Walsh SW. Plasma from preeclamptic women stimulates transendothelial migration of neutrophils. Reprod Sci. 2009 Mar;16(3):320-5. PMCID: PMC2823372

Cadden KA, Walsh SW. Neutrophils, but not lymphocytes or monocytes, infiltrate maternal systemic vasculature in women with preeclampsia. Hypertens Pregnancy. 2008;27(4):396-405. PMCID: PMC2593156