Virginia Commonwealth University

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Featured Researcher

Research Expertise and Focus

The role of insulin resistance in the polycystic ovary syndrome

Professional Highlights

Memberships and Leadership

  • Program area head of reproductive health, Interdisciplinary Women’s Health Research Program
  • President, Androgen Excess Society, 2002
  • Association of American Physicians
  • American Society for Clinical Investigation

Awards

  • VCU School of Medicine Outstanding Research Achievement Award
  • VCU School of Medicine Distinguished Mentor in Clinical Sciences Award

Education and Training

M.D., University of Pennsylvania School of Medicine, Philadelphia

Selected Publications

Legro RS, Chen G, Kunselman AR, Schlaff WD, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Zhang H, Foulds J; Reproductive Medicine Network. Smoking in infertile women with polycystic ovary syndrome: baseline validation of self-report and effects on phenotype. Hum Reprod. 2014 Dec;29(12):2680-6. doi: 10. 1093 /humrep /deu239. Epub 2014 Oct 16. PubMed PMID: 25324541; PubMed Central PMCID: PMC4227579.

Mayer SB, Evans WS, Nestler JE. Polycystic ovary syndrome and insulin: our understanding in the past, present and future. Womens Health (Lond Engl). 2015 Mar;11(2):137-49. doi: 10.2217/whe.14.73. Review. PubMed PMID: 25776288.

Adeniji AA, Essah PA, Nestler JE, Cheang KI. Metabolic Effects of a Commonly Used Combined Hormonal Oral Contraceptive in Women With and Without Polycystic Ovary Syndrome. J Womens Health (Larchmt). 2016 Feb 12. [Epub ahead of print] PMID: 26871978

Wickham EP 3rd, Tao T, Nestler JE, McGee EA. Activation of the LH receptor up regulates the type 2 adiponectin receptor in human granulosa cells. J Assist Reprod Genet. 2013;30(7):963-8. PMCID: PMC3725221

Randeva HS, Tan BK, Weickert MO, Lois K, Nestler JE, Sattar N, Lehnert H. Cardiometabolic aspects of the polycystic ovary syndrome. Endocr Rev. 2012;33(5):812-41. PMCID: PMC3461136

Roth LW, Huang H, Legro RS, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Zhang H, Schlaff WD; Reproductive Medicine Network. Altering Hirsutism Through Ovulation Induction in Women With Polycystic Ovary Syndrome. Obstet Gynecol. 2012;119(6):1151-6. PMCID: PMC3360417

Diamond MP, Kruger M, Santoro N, Zhang H, Casson P, Schlaff W, Coutifaris C, Brzyski R, Christman G, Carr BR, McGovern PG, Cataldo NA, Steinkampf MP, Gosman GG, Nestler JE, Carson S, Myers EE, Eisenberg E, Legro RS; Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Network. Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome. Obstet Gynecol. 2012;119(5):902-8. PMCID: PMC4007263

Nestler JE, Reilly ER,  Cheang KI, Bachmann LM, Downs RW Jr. A pilot study: Effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. Trans Am Clin Climatol Assoc. 2012;123:209-20. PMCID: PMC3540606

Le TN, Nestler  JE, Strauss JF 3rd, Wickham EP 3rd. Sex hormone-binding globulin and type 2 diabetes mellitus. Trends Endocrinol Metab. 2012 Jan;23(1):32-40. PMCID: PMC3351377

Aubuchon M, Kunselman AR, Schlaff WD, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, NACataldo NA, Gosman GG, Nestler JE, Myers ER, Legro RS. Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011 Oct;96(10):E1645-9. PMCID: PMC3200244

Cheang KI, Essah PA, Sharma S, Wickham EP 3rd, Nestler JE. Divergent effects of a combined hormonal oral contraceptive on insulin sensitivity in lean versus obese women. Fertil Steril. 2011 Aug;96(2):353-359.e1.  PMCID: PMC3143285

Wickham EP 3rd, Ewens KG, Legro RS, Andrea Dunaif A, Nestler JE, Strauss JF 3rd. Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011 Apr;96(4):E719-27.  PMCID: PMC3070246

Wickham EP III, Cheang KI, Clore JN, Baillargeon JP, Nestler JE. Total and high-molecular weight adiponectin in women with the polycystic ovary syndrome. Metabolism. 2011 Mar;60(3):366-72. PMCID: PMC2946975

Legro RS, Schlaff WD, Diamond MP, Coutifaris C, Casson PR, Brzyski RG, Christman GM, Trussell JC, Krawetz SA, Snyder PJ, Ohl D, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, . Gosman GG, Nestler JE, Myers ER, Santoro N, Eisenberg E, Zhang M, Zhang H. Total testosterone assays in women with polycystic ovary syndrome: precision and correlation with hirsutism. J Clin Endocrinol Metab. 2010 Dec;95(12):5305-13.   PMCID: PMC2999971

Pagidas K, Carson SA, McGovern PG, Barnhart HX, Myers ER, Legro RS, Diamond MP, Carr BR, Schlaff WD, Coutifaris C, Steinkampf MP, Cataldo NA, Nestler JE, Gosman G, Giudice LC; National Institute of Child Health and Human Development-Reproductive Medicine Network. Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network’s Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Fertil Steril. 2010 Sep;94(4):1444-6. PMCID: PMC2891817

Baillargeon JP, Iuorno MJ, Apridonidze T,  Nestler JE. Uncoupling between insulin and release of a D-chiro-inositol-containing inositolphosphoglycan mediator of insulin action in obese women With polycystic ovary syndrome. Metab Syndr Relat Disord. 2010 Apr;8(2):127-35.  PMCID: PMC3140116