Virginia Commonwealth University

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Featured Researcher

Research Expertise and Focus

Ovarian disease

Professional Highlights

Memberships and Leadership

  • Chairman, Population Research Committee of National Institute of Child Health and Human Development, 1989 – 1993
  • Member, Institute of Medicine of the National Academy of Sciences, 1994
  • President, Society for Gynecologic Investigation, 2003

Awards

  • President’s Achievement Award, Society for Gynecologic Investigation, 1990
  • Society for the Study of Reproduction Research Award, 1992
  • Transatlantic Medal of the British Endocrine Society
  • Distinguished Graduate Award, University of Pennsylvania School of Medicine, 2005
  • Distinguished Scientist Award, Society for Gynecologic Investigation, 2006

Notable

  • Luigi Mastroianni, Jr. Professor and founding director, Center for Research on Reproduction and Women’s Health,  University of Pennsylvania Medical Center
  • Chair, Board of Directors, The Burroughs Wellcome Fund

Education and Training

  • Ph.D., University of Pennsylvania, Philadelphia
  • M.D., University of Pennsylvania, Philadelphia
  • B.A., Brown University, Providence, R.I.

Selected Publications

Fettweis JM, Serrano MG, Huang B, Brooks JP, Glascock AL, Sheth NU; Vaginal Microbiome Consortium, Strauss JF 3rd, Jefferson KK, Buck GA. An emerging mycoplasma associated with trichomoniasis, vaginal infection and disease. PLoS One. 2014 Oct 22;9(10):e110943. doi: 10.1371/journal.pone.0110943. eCollection 2014. PubMed PMID: 25337710; PubMed Central PMCID: PMC4206474.

Fettweis JM, Brooks JP, Serrano MG, Sheth NU, Girerd PH, Edwards DJ, Strauss JF 3rd; Vaginal Microbiome Consortium, Jefferson KK, Buck GA. Differences in vaginal microbiome in African American women versus women of European ancestry. Microbiology. 2014 Oct;160(Pt 10):2272-82. doi: 10.1099/mic.0.081034-0. Epub 2014 Jul 29. PubMed PMID: 25073854; PubMed Central PMCID: PMC4178329.

Li X, Xu L, Li J, Li B, Bai X, Strauss JF 3rd, Zhang Z, Wang H. Otitis media in sperm-associated antigen 6 (Spag6)-deficient mice. PLoS One. 2014 Nov 13;9(11):e112879. doi: 10.1371/journal.pone.0112879. eCollection 2014. PubMed PMID: 25393619; PubMed Central PMCID: PMC4231073.

Chang JJ, Strauss JF 3rd, Deshazo JP, Rigby FB, Chelmow DP, Macones GA. Reassessing the impact of smoking on preeclampsia/eclampsia: are there age and racial differences? PLoS One. 2014 Oct 22;9(10):e106446. doi: 10.1371/journal.pone.0106446. eCollection 2014. PubMed PMID: 25337852; PubMed Central PMCID: PMC4206265.

Fettweis JM, Serrano MG, Huang B, Brooks JP, Glascock AL, Sheth NU; Vaginal Microbiome Consortium, Strauss JF 3rd, Jefferson KK, Buck GA. An emerging mycoplasma associated with trichomoniasis, vaginal infection and disease. PLoS One. 2014 Oct 22;9(10):e110943. doi: 10.1371/journal.pone.0110943. eCollection 2014. PubMed PMID: 25337710; PubMed Central PMCID: PMC4206474.

Fettweis JM, Brooks JP, Serrano MG, Sheth NU, Girerd PH, Edwards DJ, Strauss  JF 3rd; Vaginal Microbiome Consortium, Jefferson KK, Buck GA. Differences in vaginal microbiome in African American women versus women of European ancestry. Microbiology. 2014 Oct;160(Pt 10):2272-82. doi: 10.1099/mic.0.081034-0. Epub 2014 Jul 29. PubMed PMID: 25073854; PubMed Central PMCID: PMC4178329.

York TP, Eaves LJ, Neale MC, Strauss JF 3rd. The contribution of genetic and  environmental factors to the duration of pregnancy. Am J Obstet Gynecol. 2014 May;210(5):398-405. doi: 10.101 6/j.ajog.2013. 10.001. Epub 2013 Oct 2. Review. PubMed PMID: 24096276; PubMed Central PMCID: PMC3975815.

Brooks JP, Edwards DJ, Harwich MD Jr, Rivera MC, Fettweis JM, Serrano MG, Reris RA, Sheth NU, Huang B, Girerd P; Vaginal Microbiome Consortium, Strauss JF 3rd, Jefferson KK, Buck GA. The truth about metagenomics: quantifying and counteracting bias in 16S rRNA studies. BMC Microbiol. 2015 Mar 21;15:66. doi: 10.1186/s12866-015-0351-6. PubMed PMID: 25880246; PubMed Central PMCID: PMC4433096.

Allen-Daniels MJ, Serrano MG, Pflugner LP, Fettweis JM, Prestosa MA, Koparde VN, Brooks JP, Strauss JF 3rd, Romero R, Chaiworapongsa T, Eschenbach DA, Buck GA, Jefferson KK. Identification of a gene in Mycoplasma hominis associated with preterm birth and microbial burden in intraamniotic infection. Am J Obstet Gynecol. 2015 Jun;212(6):779.e1-779.e13. doi: 10.1016/j.ajog.2015.01.032. Epub 2015 Jan 28. PubMed PMID: 25637842; PubMed Central PMCID: PMC4457590.

Teves ME, Sundaresan G, Cohen DJ, Hyzy SL, Kajan I, Maczis M, Zhang Z, Costanzo RM, Zweit J, Schwartz Z, Boyan BD, Strauss JF 3rd. Spag17 deficiency results in skeletal malformations and bone abnormalities. PLoS One. 2015 May 27;10(5):e0125936. doi: 10.1371/journal.pone.0125936. eCollection 2015. PubMed PMID: 26017218; PubMed Central PMCID: PMC4446355.

Zhang L, Li W, Ni J, Wu J, Liu J, Zhang Z, Zhang Y, Li H, Shi Y, Teves ME, Song S, Strauss JF 3rd, Zhang Z. RC/BTB2 is essential for formation of primary cilia in mammalian cells. Cytoskeleton (Hoboken). 2015 Apr;72(4):171-81. doi: 10.1002/cm.21214. Epub 2015 Apr 29. PubMed PMID: 25762510.

Li W, Tang W, Teves ME, Zhang Z, Zhang L, Li H, Archer KJ, Peterson DL, Williams DC Jr, Strauss JF 3rd, Zhang Z. A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella. Development. 2015 Mar 1;142(5):921-30. doi: 10.1242/dev.119834. PubMed PMID: 25715396; PubMed Central PMCID: PMC4352978.

McAllister JM, Legro RS, Modi BP, Strauss JF 3rd. Functional genomics of PCOS: from GWAS to molecular mechanisms. Trends Endocrinol Metab. 2015 Mar;26(3):118-24. doi: 10.1016/j.tem.2014.12.004. Epub 2015 Jan 15. Review. PubMed PMID: 25600292; PubMed Central PMCID: PMC4346470.

York TP, Strauss JF 3rd, Eaves LJ. A narrow heritability evaluation of gestational age at birth. Hum Genet. 2015 Jul;134(7):809-11. doi: 10.1007/s00439-015-1574-1. Epub 2015 Jun 3. PubMed PMID: 26037287; PubMed Central PMCID: PMC4468786.

Levine DA, Karlan BY, Strauss JF 3rd. Evolving Approaches in Research and Care for Ovarian Cancers: A Report From the National Academies of Sciences, Engineering, and Medicine. JAMA. 2016 Mar 2. doi: 10.1001/jama.2016.2640. [Epub ahead of print] No abstract available. PMID: 26934631

Frey HA, Stout MJ, Pearson LN, Tuuli MG, Cahill AG, Strauss JF 3rd, Gomez LM, Parry S, Allsworth JE, Macones GA. Genetic variation associated with preterm birth in African-American women. Am J Obstet Gynecol. 2016 Mar 12. pii: S0002-9378(16)00470-1. doi: 10.1016/j.ajog.2016.03.008. [Epub ahead of print] PMID: 26979631

Bodurtha J, Strauss JF 3rd. Genomics and perinatal care. N Engl J Med. 2012 Jan 5; 366(1):64-73. PMID: 22216843

Wickenheisser JK, Biegler JM, Nelson-DeGrave VL, Richard S. Legro RS, Strauss JF 3rd, McAllister JM. Cholesterol side-chain cleavage gene expression in theca cells: augmented transcriptional regulation and mRNA stability in polycystic ovary syndrome. PLoS One. 2012; 7(11): e48963. PMCID: PMC3498373

Ewens KG, Jones MR,  Ankener W, Stewart DR, Urbanek M, Dunaif A, Legro RS, Chua A, Azziz R, Spielman RS, Goodarzi MO, Strauss JF 3rd. Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. Fertil Steril. 2011 Jun 30;95(8):2538-41.e1-6. PMCID: PMC3124609

Wickham EP III, Ewens KG, Legro RS, Dunaif A, Nestler JE, Strauss JF 3rd. Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011 Apr;96(4):E719-27.  PMCID: PMC3070246

Vadillo-Ortega F, Perichart-Perera O, Espino S, Avila-Vergara MA, Ibarra I, Ahued R, Godines M, Parry S, Macones G,  Strauss JF. Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. BMJ. 2011; 342: d2901. PMCID: PMC3100912

Hill LD, Hilliard DD, York TP, Srinivas S, Kusanovic JP, Gomez R, Elovitz MA, Romero R, Strauss JF 3rd. Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study. BMC Med Genet. 2011 May 11;12:64.  PMCID: PMC3103419

Anum EA, Retchin SM,  Garland SL, Strauss JF 3rd. Medicaid and preterm births in Virginia: an analysis of recent outcomes. J Womens Health (Larchmt)  2010 Nov;19(11):1969-75. PMCID: PMC2971635

Anum EA, Brown HL, Strauss JF 3rd. Health disparities in risk for cervical insufficiency. Hum Reprod. 2010 Nov;25(11):2894-900. PMCID: PMC2955555

Chen C, Hill LD, Schubert CM, Strauss JF 3rd, Matthews CA. Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse? Am J Obstet Gynecol. 2010 May;202(5):505.e1-5.  PMCID: PMC2866811

Anum EA, Retchin SM, Strauss JF 3rd. Medicaid and preterm birth and low birth weight: the last two decades. J Womens Health (Larchmt). 2010 Mar;19(3):443-51. PMCID: PMC2867587

Chen C, Wickenheisser J, Ewens KG, Ankener W, Legro RS, Dunaif A, McAllister JM, Spielman RS, Strauss JF 3rd. PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women. Mol Hum Reprod. 2009 Aug;15(8):459-69. PMCID: PMC2709315

Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008 Jun 19; 453(7198):1117-21. Epub 2008 May 11.

Hübner K, Fuhrmann G, Christenson LK, Kehler J, Reinbold R, De La Fuente R, Wood J, Strauss JF 3rd, Boiani M, Schöler HR. Derivation of oocytes from mouse embryonic stem cells. Science. 2003 May 23; 300(5623):1251-6. PMID: 12730498

Rocca B, Loeb AL, Strauss JF 3rd, Vezza R, Habib A, Li H, FitzGerald GA. Directed vascular expression of the thromboxane A2 receptor results in intrauterine growth retardation. Nat Med. 2000 Feb; 6(2):219-21. PMID:  10655114

Parry S, Strauss JF 3rd. Premature rupture of the fetal membranes. N Engl J Med. 1998 Mar 5;338(10):663-70. PMID: 9486996

Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C, Gu J, Rosenfeld MA, Pavan WJ, Krizman DB, Nagle J, Polymeropoulos MH, Sturley SL, Ioannou YA, Higgins ME, Comly M, Cooney A, Brown A, Kaneski CR, Blanchette-Mackie EJ, Dwyer NK, Neufeld EB, Chang TY, Liscum L, Strauss JF 3rd, Ohno K, Zeigler M, Carmi R, Sokol J, Markie D, O’Neill RR, van Diggelen OP, Elleder M, Patterson MC, Brady RO, Vanier MT, Pentchev PG, Tagle DA. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science. 1997 Jul 11; 277(5323):228-31. PMID: 9211849

Bose HS, Sugawara T, Strauss JF 3rd, Miller WL; International Congenital Lipoid Adrenal Hyperplasia Consortium. The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. N Engl J Med. 1996 Dec 19;335(25): 1870-8. PMID: 8948562

Kozarsky KF, Jooss K, Donahee M, Strauss JF 3rd, Wilson JM. Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nat Genet. 1996 May; 13(1): 54-62. PMID: 8673104

Lin D, Sugawara T, Strauss JF 3rd, Clark BJ, Stocco DM, Saenger P, Rogol A, Miller WL. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science. 1995 Mar 24; 267(5205):1828-31. PMID: 7892608