Virginia Commonwealth University

Make it real.

Featured Researcher

Research Expertise and Focus

  • Biochemical and molecular effects of antitumor drugs and radiation in breast tumor cells
  • Regulation of senescence arrest
  • Sensitization to apoptotic and autophagic cell death
  • Development of antitumor drugs
  • Mitigation of chemotherapy induced peripheral neuropathy

Professional Highlights

Membership and Leadership

  • Co-chair, sixth annual VCU Women’s Health Research Day, 2010

Education and Training

Ph.D., City University of New York,-Mount Sinai

Selected Publications

Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, Penninger J, Piacentini M, Rubinsztein DC, Simon  HU, Simonsen A, Thorburn AM, Velasco G, Ryan KM, Kroemer G. Autophagy in malignant transformation and cancer progression. EMBO J. 2015 Apr 1;34(7):856-80. doi: 10.15252/embj.201490784. Epub 2015 Feb 23. Review. PubMed PMID: 25712477; PubMed Central PMCID: PMC4388596.

Chakradeo S, Sharma K, Alhaddad A, Bakhshwin D, Le N, Harada H, Nakajima W, Yeudall WA, Torti SV, Torti FM, Gewirtz DA. Yet another function of p53—the switch that determines whether radiation-induced autophagy will be cytoprotective or nonprotective: implications for autophagy inhibition as a therapeutic strategy. Mol Pharmacol. 2015 May;87(5):803-14. doi: 10.1124/mol.114.095273. Epub 2015 Feb 9. PubMed PMID: 25667224; PubMed Central PMCID: PMC4407732.

El-Hage N, Rodriguez M, Dever SM, Masvekar RR, Gewirtz DA, Shacka JJ. HIV-1 and morphine regulation of autophagy in microglia: limited interactions in the context of HIV-1 infection and opioid abuse. J Virol. 2015 Jan 15;89(2):1024-35. doi: 10.1128/JVI.02022-14. Epub 2014 Oct 29. PubMed PMID: 25355898; PubMed Central PMCID: PMC4300622.

Chakradeo S, Elmore LW, Gewirtz DA. Is Senescence Reversible? Curr Drug Targets. 2016;17(4):460-6. PMCID: PMC Journal – In Process

Mezzaroma E, Mikkelsen RB, Toldo S, Mauro AG, Sharma K, Marchetti C, Alam A, Van Tassell BW, Gewirtz DA, Abbate A. Role of interleukin-1 in radiation-induced cardiomyopathy. Mol Med. 2015 Mar 26;21210-218. PMCID: PMC4503657

El-Hage N, Rodriguez M, Dever SM, Masvekar RR, Gewirtz DA, Shacka JJ. HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuse. J Virol. 2015 Jan 15;89(2):1024-1035. PMCID: PMC4300622

Poklepovic A, Gewirtz DA. Outcome of early clinical trials of the combination of hydroxychloroquine with chemotherapy in cancer. Autophagy. 2014 Aug;10(8):1478-1480. PMCID: PMC4203528

Sharma K, Le N, Alotaibi M, Gewirtz DA. Cytotoxic autophagy in cancer therapy. Int J Mol Sci. 2014 Jun 5;15(6):10034-51. PMCID: PMC4166015

Gewirtz DA. When cytoprotective autophagy isn’t… and even when it is. Autophagy. 2014 Mar;10(3):391-392. PMCID: PMC4077877

Sharma K, Goehe R, Beckta JM, Valerie K, Gewirtz DA. Autophagy and radiosensitization in cancer. Excli j. 2014 Feb 25;13178-191. PMCID: PMC4464266

Emery SM1, Alotaibi MR, Tao Q, Selley DE, Lichtman AH, Gewirtz DA. Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. J Pharmacol Exp Ther. 2014 Feb;348(2):293-302. PMID: 24259678

Gewirtz DA. Autophagy and senescence: A partnership in search of definition. Autophagy. 2013 May;9(5):808-812. PMCID: PMC3669198

Bristol ML, Emery SM, Maycotte P, Thorburn A, Chakradeo S, Gewirtz DA. Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? J Pharmacol Exp Ther. 2013 Mar;344(3):544-52. PMCID: PMC3583507

Toldo S, Goehe RW, Lotrionte M, Mezzaroma E, Sumner ET, Biondi-Zoccai GG, Seropian IM, Van Tassell BW, Loperfido F, Palazzoni G, Voelkel NF, Abbate A, Gewirtz DA. Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse. PLoS One. 2013 8(3):e58421. PMCID: PMC3597611

Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Valerie K, Rodier F, Davalos AR, Gewirtz DA. The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep? J Pharmacol Exp Ther. 2012 Dec;343(3):763-78. PMCID: PMC3500537

Dcona MM, Mitra D, Goehe RW, Gewirtz DA, Lebman DA, Hartman MC. Photocaged permeability: A new strategy for controlled drug release. Chem Commun (Camb). 2012 May 16;48(39):4755-4757.PMCID: PMC3500139

Bristol ML, Di X, Beckman MJ, Wilson EN, Henderson SC, Maiti A, Fan Z, Gewirtz DA. Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D 3. Autophagy. 2012 May 1;8(5):739-53. PMCID: PMC3378418

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544. PMCID: PMC3404883

Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz DA, Jaattela M, Kroemer G, et al. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 2011 Nov;7(11):1273-1294. PMCID: PMC3359482

Wilson EN, Bristol ML, Di X, Maltese WA, Koterba K, Beckman MJ, Gewirtz DA. A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D. Horm Cancer. 2011 Oct;2(5):272-85. PMCID: PMC3277402

Zhang X, Haney KM, Richardson AC, Wilson E, Gewirtz DA, Ware JL, Zehner ZE, Zhang Y. Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4627-30.  PMCID: PMC2914538

Dalyot-Herman N, Delgado-Lopez F, Gewirtz DA, Gupton JT, Schwartz EL. Interference with endothelial cell function by JG-03-14, an agent that binds to the colchicine site on microtubules. Biochem Pharmacol. 2009 Nov 1;78(9):1167-77.  PMCID: PMC2748150

Tripathi A, Fornabaio M, Kellogg GE, Gupton JT, Gewirtz DA, Yeudall WA, Vega NE, Mooberry SL. Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity. Bioorg Med Chem. 2008 Mar 1;16(5):2235-42. PMCID: PMC2362145

Arthur CR, Gupton JT, Kellogg GE, Yeudall WA, Cabot MC, Newsham IF, Gewirtz DA. Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison. Biochem Pharmacol. 2007 Oct 1;74(7):981-91. PMCID: PMC2000298

Aris SM, Gewirtz DA, Ryan JJ, Knott KM, Farrell NP. Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes. Biochem Pharmacol. 2007 Jun 1;73(11):1749-57. PMCID: PMC2716119